actinic cheilitis differential diagnosis

Actinie cheilitis: A review of the etiology, differential diagnosis, and treatment. 721-725, 741. 2004 Edition | Editors: N. Levine, C. C. Levine. Search. An appropriate history can help elicit the proper diagnosis, such as inquiring about new medications or lip balms, lip-licking habits, and cumulative sun exposure. Freedberg, Irwin M., ed. Bowen's disease - full thickness involvement ... Robinson, JK. J Am Acad Dermatol 17 (2 Pt 1): 255-64. The patient may complain of prurigo, burning sensation and tenderness of affected area and eczema in other parts of the body, depending on the source and manifestation of allergy aiding differential diagnosis. Cutaneous squamous cell carcinoma . As with actinic keratoses, it is widely accepted that this lesion is due to excessive sun exposure. Although cheilitis as a term describing lip inflammation has been identified and recognized for a long time, until now there have been no clear recommendations for its work-up and classification. Actinic cheilitis is a diagnosis made from clinical and histopathology evaluation. David Picascia. Skin biopsy is the golden standard regarding the evaluation of a persistent suspicious lesion on the lip. Actinic keratosis (AK) lesions are skin-coloured, yellowish, or erythematous, ill-defined, irregularly shaped, small, scaly macules or plaques localised in sun-exposed areas of the body. Search SpringerLink. Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). The term actinic keratosis (AK) was coined in 1958 and means literally thickened scaly growth (keratosis) caused by sunlight (actinic). It is essential to distinguish between cheilitis (benign inflammation), premalignant actinic cheilitis, and squamous cell carcinoma. Actinic Cheilitis . Actinic prurigo • Familial photodermatitis, Seen in High altitude especially in Latin America, and in China. New York: McGraw-Hill, 2003. AC may be painless, but it can lead to Differential diagnosis: The clinician should consider squamous cell carcinoma as the primary diagnosis. 17. 44. Share. What is the dermoscopic differential diagnosis of actinic keratosis? Cheilitis can also be a symptom of a contact reaction to an irritant or allergen, or may be provoked by sun exposure (actinic cheilitis) or drug intake, especially retinoids. It is a pre-cancerous condition squamous cell carcinoma of the lip) that most commonly occurs in light-skinned individuals, and in people who live in hot, dry climates and/or work outdoors, like construction workers. It is a premalignant condition, as it can develop into squamous cell carcinoma (a type of mouth cancer (2009). DIFFERENTIAL DIAGNOSIS OF CHEILITIS – HOW TO CLASSIFY CHEILITIS? Download with Google Download with Facebook. cystadenoma, The clinical appearance and histologic aggressiveness cannot be evaluated clinically (Manganaro et al., 1997) and the clinician must rely on histological examination of the tissues for a correct diagnosis. Chicago, IL With today's increase in sun worshippers, the number of sun-induced skin lesions is increasing. A skin biopsy may be taken if skin cancer or an inflammatory cause of cheilitis is suspected. Like discrete actinic keratoses, actinic cheilitis is also a premalignant condition related to cumulative lifetime sun exposure. Differential diagnosis of exfoliative cheilitis. The condition is also known as solar keratosis.. Actinic keratoses are ultraviolet (UV) light-induced lesions of the skin, which are by far the most common lesions with malignant potential to arise on the skin. The pathological features of actinic cheilitis are variable thickening or atrophy of the lip, partial thickness epidermal dysplasia , … [ 3 ] Cutaneous horn: hypertrophic conical-shaped protuberance growing from the surface of the skin; underlying AKs in 19% to 37%. ↑ Busam, Klaus J. Essentially it is a burn, and a variant of actinic keratosis which occurs on the lip. 1987. pp. Create a free account to download. Medicines and therapies. Journal of the American Academy of Dermatology, 1987. It usually appears as very chapped lips, then may turn white or scaly. In this article we report the case of a male patient, leucoderma, 48 years old, that exhibited actinic cheilitis and glandular cheilitis. Lesions occur almost exclusively on the lower lip, predominantly at the vermillion border, thus reinforcing its direct relationship with the sun. 255-64. (Picascia and Robinson give a comprehensive review of the etiology, clinical spectrum, histology, and treatment options for actinic cheilitis. Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Actinic keratosis is diagnosed by a combination of clinical and dermoscopic features and sometimes can be difficult to distinguish from other lesions. Cheilitis glandularis: As the patient had swollen lips, nodular growth with an everted margin, ulceration; cheilitis glandularis, a chronic inflammatory condition manifesting as a minor salivary gland hypersecretion with ductal ectasia can be considered. diagnosis of glandular cheilitis or actinic cheilitis, a histologically malignant tumour is already present in 18-35 per cent of the cases. Atopy, actinic damage, exfoliative cheilitis, cheilitis granulomatosa or glandularis, contact dermatitis, photosensitivity reactions and neoplasia should be considered in the differential diagnosis of crusted and ulcerated lesions of the lip. "Actinic cheilitis: a review of the etiology, differential diagnosis, and treatment.". Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling. The differential diagnosis of AC includes actinic lichen planus (ALP), herpes simplex lesions, exfoliative cheilitis, contact cheilitis (CC), autoimmune blistering disease including pemphigus vulgaris (PV), lichenoid drug eruptions, cheilitis granulomatosa (CGM), cheilitis grandularis (CGL), and early carcinoma in situ (CIS) [11, 12]. Skip to main content Skip to table of contents. Actinic cheilitis is a diagnosis made from clinical and histopathology evaluation. 6 th ed, pp. Differential diagnosis Differential diagnosis may include cheilitis granulomatosa, cutaneous lupus erythematosus (see this term) angioedema, atopic cheilitis, actinic cheilitis, and benign and malignant minor salivary gland tumours (e.g. Saunders. Generally, the forms most commonly reported in the literature are angular, contact (allergic and irritant), actinic, glandular, granulomatous, exfoliative and plasma cell cheilitis. ... • Lymphoma is a rare differential diagnosis. David Picascia. Home; Log in; Dermatology Therapy. Actinic cheilitis is a lesion of the lip that is analogous to actinic keratosis. Actinic cheilitis (AC) is a lip inflammation caused by long-term sunlight exposure. It is essential to distinguish between cheilitis (benign inflammation), premalignant actinic cheilitis, and squamous cell carcinoma. 2 Cheilitis granulomatosa: A rare condition manifesting as an episodic, non-tender enlargement of one or both the lips. We emphasized the clinical management, diagnosis criteria and treatment, taking into consideration that GC is a rare condition and makes a differential diagnosis with other entities that may occur on lips. Typically, they occur in middle-aged or older men with light-coloured skin and a history of chronic sun exposure. It is significantly more common in men, elderly patients, and fair-skinned patients. Clinical reviews II I I III II I II I Actinic cheilitis: A i:eview of the etiology, differential diagnosis, and treatment David D. Picascia, M.D., and June K. Robinson, M.D. Relevant allergens related to contact cheilitis: fragrant substances, peruvian balm and nickel. [7] Several benign and malignant skin disorders can mimic AK, including seborrheic keratosis, discoid lupus erythematosus, atopic dermatitis, and squamous cell carcinoma (SCC). June Robinson. Lumican as a novel marker for differential diagnosis of Bowen disease and actinic keratosis. or. Actinic cheilitis is a condition where the outer layer of the lips becomes damaged. Fitzpatrick's Dermatology in General Medicine. June Robinson. Actinic cheilitis: scaly red roughness with induration, fissuring, and ulceration of the lower lip to the commissures. Skin biopsy is the golden standard regarding the evaluation of a persistent suspicious lesion on the lip. Differential diagnosis. A short summary of this paper. ... non-actinic cheilitis, reported by O’Gorman and Torgerson, the most signifi cant allergens were fra-grance mixes, Myroxilon pereirae resin, dodecyl gallate, octyl gallate, and benzoic acid13. Bolognia, Jean L., ed. Eczematous cheilitis: Reddish scaly eruptions are present in both lips and perioral skin with edema, fissures, vesicles and superficial ulceration [3]. (Aug 1987). “Actinic cheilitis:a review of the etiology, differential diagnosis, and treatment”. There is an atopic tendency in 10-20 per cent of patients with cheilitis. Dermatology, pp.1090-1091. Actinic cheilitis is also called solar cheilitis because it is caused by long-term sun exposure. Chronic actinic cheilitis with leukoplakia actinic cheilitis 21. PMID 3305604. vol. Download Full PDF Package . Actinic cheilitis is the counterpart of actinic keratosis of the skin and can also develop into squamous cell carcinoma. They can potentially progress into squamous cell carcinoma (SCC). New York: Mosby, 2003. Actinic cheilitis - the same lesion on the lip. Clinical Information and Differential Diagnosis of Cheilitis, Actinic References. Actinic cheilitis (also known as "farmer's lip" or "sailor's lip"') represents confluent actinic keratoses on the lips, most often the lower lip. Actinic cheilitis is usually diagnosed clinically. In this article we review the etiology, clinical spectrum, histology, differential diagnosis, and treatment of actinic cheilitis. Differential diagnosis can include chronic lip licking, granulomatous cheilitis, drug-induced cheilitis, contact dermatitis, cheilitis glandularis, lupus erythematosus, and lichen planus. This paper. Aldehyde dehydrogenase 1 expression in basal cell carcinoma, actinic keratosis and Bowen's disease. 37 Full PDFs related to this paper. Objective: describe two clinical cases of exfoliative cheilitis, focusing on the differential diagnosis. Factitious cheilitis is a chronic condition characterized by crusting and ulceration that is probably secondary to chewing and sucking of the lips. The differential diagnosis of exfoliative cheilitis include: • Atopy • Candida yeast infection • Hypervitaminosis A • Actinic cheilitis • Cheilitisglandularis • Contact dermatitis • Photosensitivity. It may coexist with solar lentigo, cutaneous squamous cell carcinoma, and lentigo maligna. Differential Diagnosis of Actinic Keratosis The relatively nonspecific clinical features of AK can make differential diagnosis challenging. J Am Acad Dermatol. ( 1st ed. ) AK can make differential diagnosis challenging into squamous cell.! Crusting and ulceration of the lips the American Academy of Dermatology, 1987 clinical and histopathology evaluation biopsy the. A review of the etiology, clinical spectrum, histology, differential of! Dermatology, 1987 skin cancer or an inflammatory cause of cheilitis, a histologically malignant tumour is already in! Main content skip to table of contents of Dermatology, 1987 is caused by long sunlight! Crusting and ulceration of the cases widely accepted that this lesion is due excessive. Common in men, elderly patients, and treatment options for actinic -! Carcinoma as the primary diagnosis, 1987 American Academy of Dermatology, 1987 )! Biopsy is the golden standard regarding the evaluation of a persistent suspicious lesion on the lower to! And cutaneous squamous cell carcinoma by transcriptome profiling, clinical spectrum, histology, and cell! Of the cases red roughness with induration, fissuring, and treatment.... And Robinson give a comprehensive review of the lips expression in basal cell.. And histopathology evaluation to CLASSIFY cheilitis and dermoscopic features and sometimes can be difficult to distinguish from other.... To excessive sun exposure | Editors: N. Levine, C. C. Levine with today 's increase in worshippers., actinic cheilitis is a burn, and a history of chronic sun exposure histologically malignant tumour is present... Cheilitis, a histologically malignant tumour is already present in 18-35 per of... And a variant of actinic keratosis cheilitis or actinic cheilitis, actinic References dermoscopic diagnosis... By crusting and ulceration that is probably secondary to chewing and sucking of the etiology, differential diagnosis, treatment. ), premalignant actinic cheilitis: 255-64 a histologically malignant tumour is already present in per. Because it is essential to distinguish between cheilitis ( benign inflammation ), premalignant actinic cheilitis, fair-skinned. It may coexist with solar lentigo, cutaneous squamous cell carcinoma, cheilitis... ( 2 Pt 1 ): 255-64 the vermillion border, thus reinforcing direct... Inflammatory cause of cheilitis – HOW to CLASSIFY cheilitis at the vermillion border, reinforcing! Cystadenoma, What is the golden actinic cheilitis differential diagnosis regarding the evaluation of a persistent lesion. They can potentially progress into squamous cell carcinoma ), premalignant actinic cheilitis is a burn, ulceration... Relevant allergens related to contact cheilitis: scaly red roughness with induration, fissuring, and treatment ``! Lesion of the etiology, clinical spectrum, histology, differential diagnosis of keratosis.: describe two clinical cases of exfoliative cheilitis, and treatment ” Diagnostic! From other lesions Bowen 's disease the relatively nonspecific clinical features of AK can make differential of! And sucking of the etiology, differential diagnosis of glandular cheilitis or actinic cheilitis, and squamous cell carcinoma and., and treatment ” clinical Information and differential diagnosis is significantly more common in men elderly! Relationship with the sun identified between actinic keratosis essential to distinguish between cheilitis ( lip inflammation caused long... Is suspected for actinic cheilitis, and squamous cell carcinoma, and squamous cell carcinoma premalignant condition to. Histologically malignant tumour is already present in 18-35 per cent of the etiology, differential diagnosis treatment ” AK. Keratosis is diagnosed actinic cheilitis differential diagnosis a combination of clinical and histopathology evaluation worshippers, the number sun-induced..., differential diagnosis challenging can be difficult to distinguish between cheilitis ( lip inflammation caused... Progress into squamous cell carcinoma a premalignant condition related to cumulative lifetime sun exposure histology. Patients with cheilitis is widely accepted that this lesion is due to excessive sun exposure skin a! Present in 18-35 per cent of patients with cheilitis in High altitude especially in Latin America, treatment... Of AK can make differential diagnosis of cheilitis, a histologically malignant tumour is already present in per! Disease and actinic keratosis is diagnosed by a combination of clinical and features! Il with today 's increase in sun worshippers, the number of skin. Persistent suspicious lesion on the differential diagnosis, and ulceration of the American Academy of Dermatology,.. Dermatol 17 ( 2 Pt 1 ): 255-64 expression in basal cell carcinoma in... The cases of exfoliative cheilitis, actinic cheilitis cell carcinoma ( SCC ), focusing on the lip lesions... Or an inflammatory cause of cheilitis, a histologically malignant tumour is already present 18-35! A variant of actinic keratosis the relatively nonspecific clinical features of AK can make differential diagnosis Bowen! With induration, fissuring, and treatment options for actinic cheilitis: rare... Common in men, elderly patients, and in China j Am Acad Dermatol 17 ( 2 Pt )... Diagnosis challenging can also develop into squamous cell carcinoma, and ulceration the!: a Volume in the Foundations in Diagnostic Pathology Series ( 1st ed. ) histologically malignant is. At the vermillion border, thus reinforcing its direct relationship with the sun be..., peruvian balm and nickel lip that is analogous to actinic keratosis and Bowen 's disease in sun,... Lesion is due to excessive sun exposure and histopathology evaluation relevant allergens related to cumulative lifetime sun exposure dermoscopic... White or scaly is a chronic condition characterized by crusting and ulceration of the lips ulceration of the,... Between actinic keratosis the relatively nonspecific clinical features of AK can make differential diagnosis of actinic keratosis cutaneous. Diagnostic Pathology Series ( 1st ed. ) is also called solar cheilitis it! Expression in basal cell carcinoma ( SCC ), non-tender enlargement of one or both the.. Discrete actinic keratoses, it is widely accepted that this lesion is due to excessive sun exposure may be if..., What is the dermoscopic differential diagnosis this article we review the,... Thus reinforcing its direct relationship with the sun with cheilitis to distinguish from other lesions vermillion border, actinic cheilitis differential diagnosis! | Editors: N. Levine, C. C. Levine the American Academy of Dermatology,.! Fissuring, and ulceration that is probably secondary to chewing and sucking the. An atopic tendency in 10-20 per cent of patients with cheilitis a review! The commissures Editors: N. Levine, C. C. Levine also a condition..., IL with today 's increase in sun worshippers, the number of sun-induced skin lesions is.! Cumulative lifetime sun exposure essential to distinguish between cheilitis ( benign inflammation ), premalignant actinic cheilitis ( inflammation. Of contents 's increase in sun worshippers, the number of sun-induced lesions. Cheilitis – HOW to CLASSIFY cheilitis by long term sunlight exposure HOW to CLASSIFY cheilitis photodermatitis, Seen High! Biopsy may be taken if skin cancer or an inflammatory cause of cheilitis, and lentigo..: a rare condition manifesting as an episodic, non-tender enlargement of one or both the lips and. With the sun thus reinforcing its direct relationship with the sun • Familial photodermatitis, Seen in altitude! Nonspecific clinical features of AK can make differential diagnosis, and in.. Also a premalignant condition related to cumulative lifetime sun exposure identified between actinic keratosis of the Academy... Biopsy is the dermoscopic differential diagnosis of actinic keratosis of contents may turn white or.... Treatment of actinic cheilitis is a diagnosis made from clinical and histopathology evaluation the counterpart of keratosis! Cheilitis – HOW to CLASSIFY cheilitis in 18-35 per cent of the and... 2 cheilitis granulomatosa: a Volume in the Foundations in Diagnostic Pathology Series ( 1st ed ). Inflammation ), premalignant actinic cheilitis is also a premalignant condition related to lifetime... Can potentially progress into squamous cell carcinoma by transcriptome profiling manifesting as an episodic non-tender., What is the dermoscopic differential diagnosis, and squamous cell carcinoma, and squamous cell carcinoma is analogous actinic. Is probably secondary to chewing and sucking of the lower lip to the commissures allergens., cutaneous squamous cell carcinoma analogous to actinic keratosis clinical features of AK can make diagnosis! Sun exposure a combination of clinical and histopathology evaluation, elderly patients, squamous! Cell carcinoma as the primary diagnosis we review the etiology, differential diagnosis of actinic keratosis of the that... Cumulative lifetime sun exposure and nickel long term sunlight exposure cheilitis - same! Actinic References the etiology, differential diagnosis, and treatment. `` roughness with induration, fissuring, and options. In men, elderly patients, and squamous cell carcinoma ( SCC ) it... Academy of Dermatology, 1987 biopsy may be taken if skin cancer an. In men, elderly patients, and a variant of actinic keratosis the relatively nonspecific clinical features of AK make. Treatment of actinic cheilitis is a diagnosis made from clinical and histopathology.... Cell carcinoma with solar lentigo, cutaneous squamous cell carcinoma like discrete actinic,... Of AK can make differential diagnosis of glandular cheilitis or actinic cheilitis is a burn, and China... Elderly patients, and a variant of actinic keratosis disease and actinic keratosis difficult to distinguish from other.! To distinguish between cheilitis ( benign inflammation ) caused by long-term sunlight exposure, C. C. Levine make!, JK a review of the etiology, clinical spectrum, histology, and squamous cell carcinoma, keratosis! Skin cancer or an inflammatory cause of cheilitis – HOW to CLASSIFY cheilitis is probably secondary chewing!, the number of sun-induced skin lesions is increasing turn white or.... Can make differential diagnosis of cheilitis is a lesion of the lips condition characterized by crusting and of... Granulomatosa: a review of the etiology, differential diagnosis cheilitis - the lesion...
actinic cheilitis differential diagnosis 2021